Physiological Effects Of Hyperbaric Oxygenation
oooThe mechanical effect of pressure is used in reducing bubble sizes in the blood vessels following diving accidents (Bends) or iatrogenic introduction of intravascular air during injections or haemodialysis.
Effect of Oxygen Solubility in Plasma

oooOnly a limited amount of oxygen dissolved in blood at normal atmospheric pressure. Under hyperbaric conditions, it is possible to dissolve sufficient oxygen, i.e., 6% (by Volume) in plasma, to meet the usual requirements of the body.

oooIn this case, Oxyhaemoglobin will pass unchanged from the arterial to the venous side because the oxygen, physically dissolved in solution, is more readily bound to haemoglobin.

Effect of HBO2 on Microcirculation
oooHyperbaric oxygen improves the elasticity of the red blood cells and reduces platelet aggregation. This, combined with the ability of the plasma to carry dissolved oxygen to areas where red blood cells cannot reach, has a beneficial effect on the oxygenation of many Hypoxic tissues in various circulatory disorders.
Indications: Approved Uses

International Congress of Hyperbaric Medicine (ICHM) has approved indications for which Hyperbaric Oxygen (HBO2) is the primary mode of treatment or an important adjunct to other medical measures.

1. oCarbon Monoxide, Ammonia, Hydrogen Sulphide, Chemical and Petroleum Gas Poisoning.
2. oAccident Head Injuries and other Acute Traumatic Injuries in traffic accidents.
3.o Thermal and Chemical Burns.
4. oAir/Gas Embolism and Nitrogen Narcosis in Scuba Diving Accidents.
5. oDecompression Sickness in Deep Sea Diving (bends).
6. oExceptional Blood Loss Anaemia.
7. oDiabetic Foot and Pressure Ulcers.
8. oNon-Healing Problematic Wounds.
9. oOsteoradionecrosis in Radiotherapy of Cancer Patients.
10. Ostomyelitis (Refractory) in Cancers.
11. Plastic Surgery (Skin Grafts and Flaps).
12. Clostridial Myositis and Myonecrosis (Gas Gangrene) in Post-Surgery Cases.
13. Intracranial Abscess and Encephalitis due to Virus Infections.
14. Strokes and Neurological Disorders.
15. Cerebral Palsy in Near Drowning, near Hanging, Forceps Babies, Autism and Dyslexia.
16. Multiple Sclerosis.
17. Ophthalmological Problems like Retina Detachment or Central Retinal Artery Occlusion (CRAO).
18. Anti-Ageing Treatment.
19. Cosmetic Value Treatment (Michael jackson’s Therapy).
20. Athletic Sports Medicine and Aero Medicine.


Therapeutic effects of Hyperbaric oxygen:

Related to the ability of oxygen tension under hyperbaric conditions to:

  1. Promote Cellular proliferation (e.g.restoration of Fibroblast growth and enhancement of osteoclast activity in tissue healing).
  2. Reverse Hypoxia in coma patients.
  3. Alter Ischemic effects (short supply of oxygen).
  4. Influence Vascular Reactivity (e.g. decrease in White Blood Cell adherence to capillary walls).
  5. Reduce edema (Swellings).
  6. Modulate Nitric Oxide production.
  7. Modify Growth Factors (IGF) and Cytokine effect by regulating their levels of receptors in wound healing.
  8. Induce changes in membrane proteins affecting on exchanges and gating mechanisms (e.g.preservation of ATP in cell membranes).
  9. Accelerate Collagen deposition in tissue healing.
  10. Stimulate capillary budding & arborization (Increase capillary proliferation in tissue healing).
  11. Accelerate microbial oxidative killing (enhancement of Leucocytes-killing activity in HIV-AIDS patients).
  12. Improve selected antibiotics exchange across tissue membranes.
  13. Interfere with bacteria propagation by denaturing toxins (suppression of Alpha-toxin production in gas gangrene of problematic wounds).
  14. Modulate Immune System Response (stimulation of Superoxide Dismutase (SOD) production).
  15. Enchance Oxygen Free Radical Scavengers (decrease Ischemia-Reperfusion injury; termination of Lipid Peroxidation in Carbon Monoxide, Chemical and Petroleum Gas Poisoning).
All Rights Reserved @ Hitech Hyperbaric Medical Centre, Malaysia.