Physiological Effects Of Hyperbaric
mechanical effect of pressure is used in reducing bubble sizes
in the blood vessels following diving accidents (Bends) or
iatrogenic introduction of intravascular air during injections
Effect of Oxygen Solubility in
oooOnly a limited amount of
oxygen dissolved in blood at normal atmospheric pressure.
Under hyperbaric conditions, it is possible to dissolve
sufficient oxygen, i.e., 6% (by Volume) in plasma, to meet the
usual requirements of the body.
case, Oxyhaemoglobin will pass unchanged from the arterial to
the venous side because the oxygen, physically dissolved in
solution, is more readily bound to
Effect of HBO2 on
oxygen improves the elasticity of the red blood cells and
reduces platelet aggregation. This, combined with the ability
of the plasma to carry dissolved oxygen to areas where red
blood cells cannot reach, has a beneficial effect on the
oxygenation of many Hypoxic tissues in various circulatory
International Congress of Hyperbaric Medicine
(ICHM) has approved indications for which Hyperbaric
Oxygen (HBO2) is the primary mode of
treatment or an important adjunct to other medical measures.
Monoxide, Ammonia, Hydrogen Sulphide, Chemical and Petroleum
2. oAccident Head Injuries
and other Acute Traumatic Injuries in traffic
3.o Thermal and
4. oAir/Gas Embolism and Nitrogen Narcosis
in Scuba Diving Accidents.
5. oDecompression Sickness in Deep Sea
6. oExceptional Blood Loss
7. oDiabetic Foot and Pressure
9. oOsteoradionecrosis in Radiotherapy of
(Refractory) in Cancers.
Plastic Surgery (Skin Grafts and
12. Clostridial Myositis and Myonecrosis (Gas
Gangrene) in Post-Surgery Cases.
Intracranial Abscess and Encephalitis due to Virus
14. Strokes and
Cerebral Palsy in Near Drowning, near
Hanging, Forceps Babies, Autism and Dyslexia.
Problems like Retina Detachment or Central
Retinal Artery Occlusion (CRAO).
Cosmetic Value Treatment (Michael jackson’s
20. Athletic Sports Medicine and
Therapeutic effects of Hyperbaric
Related to the
ability of oxygen tension under hyperbaric conditions
- Promote Cellular proliferation
(e.g.restoration of Fibroblast growth and enhancement
of osteoclast activity in tissue healing).
- Reverse Hypoxia in coma
- Alter Ischemic effects (short supply of
- Influence Vascular Reactivity
(e.g. decrease in White Blood Cell adherence to
- Reduce edema (Swellings).
- Modulate Nitric Oxide production.
- Modify Growth Factors (IGF)
and Cytokine effect by regulating
their levels of receptors in wound healing.
- Induce changes in membrane proteins affecting
on exchanges and gating mechanisms (e.g.preservation
of ATP in cell membranes).
- Accelerate Collagen deposition
in tissue healing.
- Stimulate capillary budding
& arborization (Increase capillary proliferation
in tissue healing).
- Accelerate microbial oxidative killing
(enhancement of Leucocytes-killing
activity in HIV-AIDS patients).
- Improve selected antibiotics
exchange across tissue membranes.
- Interfere with bacteria propagation by
denaturing toxins (suppression of Alpha-toxin
production in gas gangrene
of problematic wounds).
- Modulate Immune System Response (stimulation
of Superoxide Dismutase (SOD)
- Enchance Oxygen Free Radical Scavengers
(decrease Ischemia-Reperfusion injury; termination
of Lipid Peroxidation in Carbon Monoxide, Chemical
and Petroleum Gas Poisoning).