[Lecba ischemickych mozkovych cevnich prihod
Vnitr Lek 1992 Jul;38(7):645-50 (ISSN:
Berger J; Emmerova M; Hadravsky M; Kratky M;
Vetrovcova J; Berkova E Neurologicka klinika FN Plzen.
The authors present eleven year's experience
with comprehensive treatment of patients who suffered an ischemic
cerebrovascular attack. This comprises so-called conventional
treatment of cerebrovascular attacks and also hyperbaroxia, i.e.
administration of oxygen under high partial pressure. The authors
used a therapeutic pressure of 0.2 MPa for 90 minutes in individual
exposures. Of 31 treated patients 23 improved, i.e. 76%; eight
improved slightly, eight significantly and seven substantially. The
condition of the remainder did not change.
Hyperbaric Oxygen Therapy should therefore be
used everywhere where this method is available.
for brain injury - the rationale behind the myth
Alex ; G Laden ; S C Griffin ; M E Cowen ; A R J Cale ; L Guvendik
Source: Clinical Intensive Care Volume: 13 Number: 2 Page: 57 --
Publisher: BIOS Scientific Publishers Ltd
Brain injury can have serious physical, mental,
and socio-economic impact on a patient's life. The type of injury
can be either ischaemic or traumatic but the final common pathway is
the release of cytokines and activation of the inflammatory cascade
and other mediators of cellular injury. The severity of neurological
and neuropsychological impairment can be described in two ways,
behaviorally and structurally.
Behavioral impairment describes the human
condition. A small left-hemispheric central cortical injury, in a
patient with left hemisphere dominance, resulting in expressive
dysphasia, dominant hand weakness, and eye movement in coordination,
is a socio-economic disaster for the patient. Conversely, a larger
anterior right frontal lobe injury may go unnoticed, although
causing a greater level of tissue destruction. From these examples
we can see that the quantity of the tissue damage (structural
impairment) does not necessarily correlate with the socio-economic
consequences of brain injury.
Treatment of brain injury focuses on trying to
remove the cause, restore perfusion, support the metabolic
requirement, and limit the inflammatory response and oxidative
damage. Hyperbaric oxygen has been used as a therapeutic adjunct in
the treatment of brain injured patients. There are both proponents
and opponents to this form of therapy. Most published human studies
claim a significant and demonstrable improvement in clinical
outcome. The results of animal studies indicate that hyperbaric
oxygen may have a beneficial effect by inducing tolerance to
ischaemia reperfusion injury in the central nervous system. In this
review we try to understand the mechanism of this beneficial effect
by looking at the effect of hyperbaric oxygen on inflammatory